One potential complication is tissue leakage, which can cause skin staining. Every precaution is taken to minimize this risk, though in rare cases, the stain may be permanent.
Some individuals experience temporary flushing reactions. These reactions typically occur within minutes of starting the infusion and can be managed by slowing or briefly pausing the process.

In approximately 1-2% of cases, individuals may experience brief symptoms such as flushing, light headedness, dry cough, chest tightness, nausea, or dizziness. These typically resolve within 20-40 seconds when the infusion is paused. If needed, an antihistamine or steroid may be administered.

Hives or skin rashes occur in about 1 in 200-500 patients, which is why post-infusion observation for 30 minutes is advised. These reactions usually resolve with antihistamines, and individuals prone to allergies may be advised to take antihistamines pre-emptively.

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